In Buddhism the Four Noble Truths are traditionally identified as the first teaching given by the Buddha, and considered one of the most important teachings in Buddhism.
The Four Noble Truths are:
Dukkha (suffering, incapable of satisfying, painful) is an innate characteristic of existence in the realm of samsara;
Samudaya (origin, arising) of this dukkha, which arises or "comes together" with taṇhā ("craving, desire or attachment");
Nirodha (cessation, ending) of this dukkha can be attained by the renouncement or letting go of this taṇhā;
Magga (path, Noble Eightfold Path) is the path leading to renouncement of tanha and cessation of dukkha.